Morphine Induces Splenocyte Trafficking into the CNS
نویسندگان
چکیده
منابع مشابه
Mechanisms of leukocyte trafficking into the CNS.
HIV-1 encephalitis occurs in up to one-third of HIV-1-infected individuals. The mechanisms through which this pathology develops are thought to involve viral passage across the blood-brain barrier (BBB), as well as entry of HIV-infected and/or uninfected inflammatory cells into the central nervous system (CNS). Viral proteins and cytokines may also contribute to the pathogenesis of encephalitis...
متن کاملTrafficking of lymphocytes into the CNS
Immune cell migration over the blood-brain barrier into the central nervous system has been a topic of research for the last century, but it has gained significant momentum 20 years ago with the possibility of blocking adhesion molecules with monoclonal antibodies and use these as a therapeutic avenue for immune-mediated tissue damage(Yednock et al., 1992). In principle this concept applies to ...
متن کاملMicroinjection of orexin-A into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
Introduction: It has been shown that orexin peptides have a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. However, LC neurons do not show withdrawalinduced hyperactivity in the brain slices from morphin...
متن کاملMicroinjection of WIN55,212-2 as a Cannabinoid Agonist into the Basolateral Amygdala Induces Sensitization to Morphine in Rats
Introduction: Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in cannabinoid-induced antinociception. Also, it seems that there are functional interactions between the cannabinoid CB1 and opioid receptors in the process of sensitization to opiates. In the present study, we tried to examine the role of intra-BLA cannabinoid rece...
متن کاملmicroinjection of orexin-a into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
introduction: it has been shown that orexin peptides have a role in opioid withdrawal behaviors. orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the locus coeruleus (lc). withdrawal syndrome is temporally associated with hyperactivity of lc neurons. however, lc neurons do not show withdrawalinduced hyperactivity in the brain slices from morphine-d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroimmune Pharmacology
سال: 2011
ISSN: 1557-1890,1557-1904
DOI: 10.1007/s11481-011-9307-2